Structural Diversity and Role of Phytochemicals against P38-α Mitogen-activated Protein Kinase and Epidermal Growth Factor Receptor Kinase Domain: A Privileged Computational Approach

Computational databases and tools in recent times have been proved to provide an essential aid for anticancer studies the field of oncology. Molecular docking facilitate structural diversity plant-derived phytomolecules having properties against receptor proteins involved cancer signaling pathways. The current study involves investigation phytocompounds-agasthisflavone, anacardic acid, zoapatanolide A, a purified product plant extract Amarogopinois546 were subjected on p38-α MAPK EGFR Kinase domain. effectiveness this was evaluated by comparing interactions standard drug, doxorubicin molecules. is analyzed compound estimated with lowest binding energy considered highest affinity towards active site proteins. isolated displayed least score large number hydrogen bonds hydrophobic P38α MAP kinase comparison This preliminary result can strongly be supported carrying out experimental evaluation near future.